STRONTIUM AND CALCIUM METABOLISM IN METABOLIC BONE DISEASES *

Strontium and Calcium Metabolism in Metabolic Bone

Skeletal and systemic disease may be reflected in profound alterations of the metabolism of the bone salts. In human skeletal disease attention has focused, for the most part, on the altered metabolism of calcium. Several studies indicate that strontium may have a metabolic pathway similar to that of calcium and that radiostrontium, because of its ease of measurement, might be a convenient indi...

Strontium and its relation to calcium metabolism.

The relative retention of strontium and calcium in bone tissue.

The presence of strontium in the bone tissue of vertebrates has been reported by a number of investigators (l-6), although at least two workers found none in the samples analyzed (7, 8). The behavior of strontium in the animal body is of some interest, for, although its metabolic fate is very similar to that of calcium, it cannot supplant calcium in the diet without causing severe disturbances ...

Glucocorticoids, metabolism and metabolic diseases.

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical components of the delicate hormonal control system that determines energy homeostasis in mammals. Whereas physiological levels of GC...

Effect of High Calcium Intake on Strontium Metabolism in Man.

Studies carried out with tracer doses of radiostrontium (Sr85) in man have revealed qualitative similarities but quantitative differences in metabolism of strontium and calcium (1-5). The principle of qualitative correlation between urinary excretion of calcium and of radiostrontium has been utilized in investigations of the removal of radiostrontium from man (6). It has been shown that elimina...